Case Study:Mouse monoclonal antibody development against Fructans (Inulin and Levan)

Antibodies are compelling proteins that are essential to the immune system and extremely powerful in biotechnology applications; existing as major players in our defence against external agents (viruses, bacteria, etc.), they are also widely used as tools for research.

Custom antibody development is based on a number of criteria. One of the crucial parameters for obtaining good antibodies is the immunogenicity of the target, i.e. its ability to induce an immune response in the host receiving the target.

As in the case of small chemical molecules, fructans and other oligosaccharides are targets for which it is difficult to obtain antibodies due to their very small size and consequently low immunogenicity.

With over 40 years’ experience, BIOTEM has developed unique expertise in developing antibodies against challenging targets. Our teams have developed optimized strategies for conjugating small molecules to improve their immunogenicity. Combined with a tailored immunization and screening approach, BIOTEM’s development programs increase the chances of success and the production of high-quality antibodies.

Today, BIOTEM would like to share with you the results of one of the projects carried out for the University of Caen Normandie and Rouen Normandie. With the validation of our client, our teams successfully met the challenge of developing high-performance antibodies directed against fructans (Inulin and Levan), fructose polymers.

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By Jonathan MAYALI

Case Study: Antibody against Fructans

PRESS RELEASE: e-FabRIC Project

Advanced Therapies 2024

Case Study:Mouse monoclonal antibody development against Fructans (Inulin and Levan)

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